Complete genome sequence of potential probiotic Ligilactobacillus ruminis CACC881 isolated from swine

<italic>Ligilactobacillus ruminis</italic> is a gram-positive anaerobic bacterium<italic> </italic>in the host intestinal tract. <italic>L. ruminis </italic>has not been extensively studied, resulting in limited data regarding its potential probiotic properties and genomic information. In this study, the genome of <italic>L. ruminis </italic>CACC881 was comprehensively analyzed, resulting in the prediction of potential probiotic characteristics. Additionally, a comparative genomic analysis was conducted on the five <italic>L. ruminis</italic> strains. The genome of strain CACC881 comprised one circular chromosome 2,107,343 bp in length. Among the predicted 1,935 protein-coding genes, the genome included genes associated with potential probiotic properties, such as acid/bile salt tolerance, CRISPR-related genes, and vitamin B-group genes. Notably, the genes for bacteriocin regulation/immunity (<italic>nisK</italic> and <italic>nisI</italic>) and antioxidant activity (<italic>ahpC</italic>) were exclusively found in strain CACC881, while absent in the other four <italic>L. ruminis</italic> genomes. These findings suggest that <italic>L. ruminis </italic>CACC881 is a potential probiotic with applications for the animal industry.