Table 4. Enriched metabolic pathways of the gut microbiota in HT compared to LT

Pathway Code (MetaCyc) Pathway Name ALDEx difference Metabolite
PWY-6588 Pyruvate fermentation to acetone 2.29 Acetone
PWY-7373 Superpathway of demethylmenaquinol 6 biosynthesis II 2.10 Demethylmenaquinol-6
PWY-7198 Pyrimidine deoxyribonucleotides de novo biosynthesis IV 2.02 dTTP
P163-PWY L-lysine fermentation to acetate and butanoate 1.92 Acetate
PWY-7210 Pyrimidine deoxyribonucleotides biosynthesis from CTP 1.91 dCTP, dTTP
PWY-5177 Glutaryl-CoA degradation 1.86 Acetyl-CoA
PWY-7456 Mannan degradation 1.63 β-D-fructofuranose 6-phosphate
PWY-5823 Superpathway of CDP-glucose-derived O-antigen building blocks biosynthesis 1.45 CDP-α-D-tyvelose, CDP-ascarylose
RHAMCAT-PWY L-rhamnose degradation I 1.44 (S)-lactaldehyde, Glycerone phosphate
PWY-7315 dTDP-N-acetylthomosamine biosynthesis 1.36 dTDP-4-acetamido-α-D-fucose
HT, high-performance Thoroughbreds; LT, low-performance Thoroughbreds; ALDEx, ANOVA-Like Differential Expression.