| PWY-7527 | L-methionine salvage cycle III | 5.68 | 2-oxoglutarate |
| PWY-4361 | S-methyl-5-thio-α-D-ribose 1-phosphate degradation | 5.48 | 2-oxoglutarate, L-methionine |
| PWY-7616 | Methanol oxidation to carbon dioxide | 5.46 | CO2 |
| PWY-6731 | Starch degradation III | 4.38 | D-glucopyranose 6-phosphate |
| PWY-5183 | Superpathway of aerobic toluene degradation | 3.86 | Acetyl-CoA, Succinyl-CoA |
| PWY-6562 | Norspermidine biosynthesis | 3.79 | Norpermidine |
| PWY-7007 | methyl ketone biosynthesis | 3.39 | A methyl ketone |
| PWY-5181 | Toluene degradation III (aerobic) (via p-cresol) | 3.35 | Succinyl-CoA |
| KETOGLUCONMET-PWY | Ketogluconate metabolism | 3.32 | D-gluconate 6-phosphate |
| 3-HYDROXYPHENYLACETATE-DEGRADATION-PWY | 4-hydroxyphenylacetate degradation | 3.29 | Succinate |